PuraStat reduces delayed bleeding after colorectal submucosal dissection: a new study presented at ESGE Days 2024

Delayed bleeding represents an important postoperative complication following endoscopic submucosal dissection (ESD).

Presented by L. Schmutte et al. at the ESGE Days 2024, this new retrospective study compared the delayed bleeding rate within 30 days after ESD with and without PuraStat’s application. In a cohort group of N=225 patients, N=108 (48%) received PuraStat after resection (1).

Below is shown the notable impact of PuraStat application on delayed bleed rates, compared with the control group:

Resection sites

Delayed Bleed Rates (%)

With PuraStat

Without PuraStat







No adverse events related to PuraStat occurred. 

In conclusion, the study outcomes demonstrated that PuraStat’s application after ESD can significantly reduce the incidence of delayed bleeding, particularly in the colorectum, highlighting its safety and efficacy (2).  

Click here to read the full abstract.  


(1)  Schmutte, L., Ulrich, J., Wießner, J. R., Heilmaier, M., Schlag, C., & Abdelhafez, M. (2024). A self-assembling peptide reduces delayed bleeding after endoscopic submucosal dissection in the colorectum – a retrospective single center cohort study. Endoscopy. https://doi.org/10.1055/s-0044-1782958

(2)  PuraStat IFU 007-Rev 2; PuraStat IFU 011-Rev 2 



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