---
title: A Meta-Analysis Proves PuraStat Efficacy in Reducing Post-Procedural Delayed Bleeding after Endoscopic Resections of Gastrointestinal Lesions
description: A new meta-analysis evaluated the available data addressing the use of PuraStat to reduce delayed bleeding in patients undergoing advanced endoscopic resection of gastrointestinal lesions.
---

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# [A Meta-Analysis Proves PuraStat Efficacy in Reducing Post-Procedural Delayed Bleeding after Endoscopic Resections of Gastrointestinal Lesions](https://news.3dmatrix.com/purastat-in-endoscopic-resection)

 Written by [3-D Matrix](https://news.3dmatrix.com/author/3-d-matrix) | Jun 8, 2023 10:30:00 AM

Despite the high technical success rates of endoscopic resections (ER), post-procedural delayed bleeding is still a major complication with rates of 2% to 15%, especially in high-risk situations.

The main risks for delayed bleeding include: the location of the resection site, the resected lesion's size, and the use of antiplatelet, anticoagulant, or non-steroidal anti-inflammatory drugs (NSAIDs). The success of the employed techniques to reduce delayed bleeding, such as prophylactic clipping and coagulation, has been suboptimal and has shown varied results.

A new meta-analysis from Dr Neil Sharma *et al*. (United States), evaluated the available data addressing the use of **[PuraStat](https://3dmatrix.com/products/purastat/)** to reduce delayed bleeding in patients undergoing advanced endoscopic resection of gastrointestinal lesions (esophageal, gastric, duodenal, colorectal).** **Electronic databases (PubMed, Embase, and Cochrane Library) from January 2010 through October 2022 were searched. Pooled proportions were calculated using fixed (inverse variance) and random effects (DerSimonian-Laird) models.

The primary outcome evaluated was [PuraStat](https://3dmatrix.com/products/purastat/)'s efficacy in preventing post-procedural delayed bleeding after advanced endoscopic resection of gastrointestinal luminal lesions.  
Secondary outcomes were: rate of delayed bleeding, adverse event rate, and PuraStat ease of use (as reported by the endoscopist).

The final analysis included data from 6 studies comprising 307 patients. Among these, 36% were on antithrombotic medications. Endoscopic submucosal dissection (ESD) was used in 72.69%, while endoscopic mucosal resection (EMR) was used in 26.42% of the procedures. 

The weighted mean size of resected lesions treated with prophylactic [PuraStat](https://3dmatrix.com/products/purastat/) was 36.2 mm. The pooled rate of delayed bleeding was 5.73%.

No adverse events were attributable to PuraStat use.

The authors stated that “*these results are comparable and better than other modalities used previously to prevent delayed bleeding after advanced endoscopic resections (ER) [...]. [PuraStat] appears promising in reducing post-procedural delayed bleeding after advanced endoscopic resection of high-risk gastrointestinal lesions, with no reported adverse events*”. 

Click [here](https://www.researchgate.net/publication/369335881_Efficacy_of_self-assembling_peptide_in_mitigating_delayed_bleeding_after_advanced_endoscopic_resection_of_gastrointestinal_lesions_A_meta-analysis#:~:text=Self-assembling%20peptide%20solution%20appears%20promising%20in%20reducing%20post-procedural,high-risk%20gastrointestinal%20lesions%20with%20no%20reported%20adverse%20events.) to read the full study.

For application within GI, PuraStat is indicated for(1):  
- Bleeding from small blood vessels and oozing from capillaries of the GI tract following surgical procedures and the surrounding tissues.  
- PuraStat is also indicated for the reduction of delayed bleeding following gastrointestinal endoscopic submucosal dissection (ESD) procedures in the colon.   
(1) - PuraStat IFU-007 Rev-2

[View full post](https://news.3dmatrix.com/purastat-in-endoscopic-resection)

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