--- title: "PuraStat Inhibitory Effect on Post-Operative Abdominal Adhesion Formation: A Promising New Preclinical Randomized Animal Study" description: New animal data with PuraStat, a haemostatic absorbable hydrogel, is now available in the publication by Eun Seok Gil, Elton Aleksi and Lisa Spirio... image: https://news.3dmatrix.com/hubfs/20190514%20Research.jpeg --- ![](https://news.3dmatrix.com/hubfs/20190514%20Research.jpeg) # PuraStat Inhibitory Effect on Post-Operative Abdominal Adhesion Formation: A Promising New Preclinical Randomized Animal Study Published by [ 3-D Matrix ](https://news.3dmatrix.com/author/3-d-matrix) on Jan 17, 2022 11:00:00 AM New animal data with PuraStat, a haemostatic absorbable hydrogel, is now available in the publication “*PuraStat RADA16 Self-Assembling Peptide Reduces Postoperative Abdominal Adhesion Formation in a Rabbit Cecal Sidewall Injury Model*” by Eun Seok Gil, Elton Aleksi and Lisa Spirio in Frontiers in Bioengineering and Biotechnology Biomaterials (2021). In clinical practice, post-operative abdominal adhesion rates are consistently high and practical means to reduce adhesion formation remain largely limited or insufficient. This animal study demonstrated the potential value of a future clinical study on PuraStat as a safe and effective interventional approach for reducing adhesion formation after abdominal surgery. The study, funded by 3-D Matrix, Ltd., Tokyo Japan, shows promising results: PuraStat intraoperative administration led to a significant reduction of abdominal adhesion formation, extent, strength, and durability. The adhesion presence was 90% in the control group vs 25% in the PuraStat group. The total adhesion score (extent + strength) was 76% lower in the PuraStat group. The adhesion coverage area was 79% lower in the PuraStat group. The adhesion durability was 72% lower in PuraStat group. The hydrogel provides temporary physical separation of the recuperating tissues, which may be sufficient to prevent adhesion between tissues and allow for regenerative wound healing. In this study PuraStat application was associated with notably superior non-adhesive healing of the lesions. You can read the full publication via [[here](https://www.frontiersin.org/articles/10.3389/fbioe.2021.782224/full?utm_source=news&utm_medium=blog#%3A%7E%3Atext=Conclusion%3A+PuraStat+treatment+has+a%2Cand+overlying+peritoneal+sidewall+defect.)] [Back to Blog](https://news.3dmatrix.com) ## Related Articles ## [PuraStat shows its efficacy in achieving endoscopic haemostasis in postoperative anastomotic ulcers](https://news.3dmatrix.com/purastat-shows-its-efficacy-in-achieving-endoscopic-haemostasis-in-postoperative-anastomotic-ulcers) A new interesting case report highlights the efficacy of PuraStat for achieving endoscopic... [Read More ](https://news.3dmatrix.com/purastat-shows-its-efficacy-in-achieving-endoscopic-haemostasis-in-postoperative-anastomotic-ulcers) ## [A Meta-Analysis Proves PuraStat Efficacy in Reducing Post-Procedural Delayed Bleeding after Endoscopic Resections of Gastrointestinal Lesions](https://news.3dmatrix.com/purastat-in-endoscopic-resection) Despite the high technical success rates of endoscopic resections (ER), post-procedural delayed... [Read More ](https://news.3dmatrix.com/purastat-in-endoscopic-resection) ## [RADA16 use in Plastic surgery (facelift): a pilot study with an optimised application technique](https://news.3dmatrix.com/rada16-use-in-plastic-surgery-facelift-a-pilot-study-with-an-optimized-application-technique) The facelift is one of the most common cosmetic surgeries performed. Although the procedure is... [Read More ](https://news.3dmatrix.com/rada16-use-in-plastic-surgery-facelift-a-pilot-study-with-an-optimized-application-technique) - - - -